In recent times, PDX models or patient-derived xenograft models are getting heavily utilized in head and neck oncology research, specifically for studies on radiation response and organoids. What is a Patient-Derived Xenograft? Patient-derived xenografts (PDX) are xenograft models that have been derived from patient tumor tissues but never adapted to grow like cell line-derived xenografts. Patient-derived...
Organoids are ex vivo model systems that revolutionized basic and translational cancer research in the domain of disease biology, since last decade. Organoid 3D cultures undergo mitogen-mediated proliferation as multicellular structures in semisolid matrices and while they possess some similarities like 3D spheroid cultures of cell lines, there are basic fundamental differences between them (Tsai...
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