In recent years, there has been increased concern over the In Vitro reproducibility of observations in life science research, particularly in light of negative experiences with preclinical in vivo research. In vivo research is gradually being supplanted by cell-based systems, and the use of in vitro models is becoming more widespread. In the realm of...
Mesenchymal stem cells (MSCs) are multipotent adult stem cells. Being mutipotent, MSCs can differentiate into more than one specialized cell of the body. Generally, MSCs make the different cells in skeletal tissues e.g., chondrocytes, osteoblast, adipocyte etc. In case of MSCs giving rise to other specialized cells like neurons, reprogramming of the cells with gene...
Multiples studies are being undertaken for mesenchymal stem cell transplantation in various neurological diseases like autism, stroke, cerebral palsy, etc.
The human umbilical cord tissue was regarded as medical waste until 1991 when fibroblast-like cells were isolated from the human umbilical cord tissue. Further characterization of these cells revealed that they express adhesion molecules (CD44, CD105), integrin markers (CD29, CD51), and mesenchymal stem cell markers like SH2 or SH3. Pluripotency markers like Oct-4, SSEA-1, and...
Antibiotics have been a routinely used component in cell cultures to prevent the growth of bacteria but several researchers doing primary cell culture have showed their interest in avoiding them for several reasons in order to save their cultures and help the cells grow happy! Researchers unanimously agree on the saying, “With good lab practice,...
3D printing was first developed in 1984 and slowly started making its way into several domains of technology. In recent times, 3D printing advancements have paved the way for using this technology in a cost-effective and efficient manner. Since the last few years, biomedical science companies have also started figuring out how to utilize this...
While the world awaits a much-anticipated COVID-19 vaccine to be approved and distributed globally, several treatment options with repurposed drugs and alternative therapies are being sought after against the coronavirus disease. Among these resources, stem cell therapy has become a popular candidate with reports of successful treatment in small cohorts across the world. But do...
According to a study by the GBD Chronic Kidney Disease Collaboration (2020), the incidence of chronic kidney disease (CKD) was 697·5 million or 9.1% in 2017: an increase of 29·3% from what was reported in 1990. The loss of lives due to CKD increased by 41·5% between 1990 and 2017! CKD is a risk factor...
One of the major causes of acute kidney injury (AKI) is sepsis: this becomes significant given that 1–35% of hospitalized patients develop AKI. In the case of general surgery, the incidence of AKI is close to 1% but this figure reaches a whopping 70% for critically ill patients accounting for in-hospital mortality of 50% in...
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