The stem cells that produce all other blood cells are known as hematopoietic stem cells (HSCs). Hematopoiesis is the name for this process. Hematopoietic stem cells (HSC) are the instigators behind definitive hematopoiesis or the continual synthesis of blood cells throughout the lifespan of an organism. Each HSC is developed to produce the cellular blood...
In recent years, there has been increased concern over the In Vitro reproducibility of observations in life science research, particularly in light of negative experiences with preclinical in vivo research. In vivo research is gradually being supplanted by cell-based systems, and the use of in vitro models is becoming more widespread. In the realm of...
When you are starting your cell culture research, the primary requirement is having cells, and to decide whether human primary cells or cell lines will be beneficial, is a major task! If you want a cell culture model that is closer to human in vivo environment, human primary cells are a better choice. Human primary...
Primary cells mimic the tissue of origin as they are directly isolated from the tissue and processed for culturing under optimized media conditions. Therefore, primary cell culture provides excellent model systems for studying normal cell physiology and biochemistry. There are a lot of articles on primary cells vs cell lines to understand which one of them...
Human bone marrow-derived mesenchymal stem cells (MSCs) have elicited great interest in the domains of tissue engineering, wound healing, regenerative medicine, and transplantation. Previous research studies have demonstrated that the transplantation of MSCs to an ectopic site in animal models has given rise to osteoblasts and bone tissue. Human bone marrow-derived mesenchymal stem cells are...
Cell culture is a prominent tool in cellular and molecular biology research, often spreading to clinical applications. Cell culture using primary cells can be excellent model systems for studying physiology and biochemistry of cells, drug toxicity and metabolism, and other biomedical applications. Primary cell culture is being used by researchers worldwide for their role in...
In biomedical research and development, scientists mostly use cultured cell lines as models because they offer easy, inexpensive, and stable platforms. However, cell lines fail to grasp the microenvironment physiology that occurs in vivo. Human primary cells come to the rescue in this situation! Primary cell culture portrays the complex physiological cell behavior and therefore...
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