The human umbilical cord tissue was regarded as medical waste until 1991 when fibroblast-like cells were isolated from the human umbilical cord tissue. Further characterization of these cells revealed that they express adhesion molecules (CD44, CD105), integrin markers (CD29, CD51), and mesenchymal stem cell markers like SH2 or SH3. Pluripotency markers like Oct-4, SSEA-1, and...
This article reviews the status of PARP inhibitors for prostate cancer treatment and focuses on recent developments in drug approvals. How PARP Inhibitors help in Prostate Cancer Treatment? Prostate cancer is a heterogeneous disease, often driven by specific genomic alterations. The defects in DNA repair/DNA-damage response pathways are critical to the risky malignant transformation of...
Preclinical research models of cancer, such as human tumor xenografts, murine tumor homografts, cell line models and 3D organoid models, are extensively used in research and development for oncology studies. Since these tumor models are used for a wide spectrum of research applications, they are often utilized globally but the cell lines which are used...
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