Swine Tumor Cells

The establishment of animal models for understanding the pathophysiology of cancer biology is currently being practiced at a higher pace. Traditionally, rodent models have supported an understanding of the basic mechanism of oncogenesis further extrapolating them to treatment strategies, rodents limit their ability to reflect all the attributes of the disease conditions that are associated with particular cancer. Thus, a translational approach based on small animal research to clinical application on humans can be quite challenging due to a lot of metabolic differences and response stimuli. At the same time, it is very important to understand that due to the short lifespan of small animals it

is very difficult to utilize them for longitudinal studies in order to assess the safety and efficacy of a new drug and understand drug kinetics. On the contrary large animals with similar genetic and physiological attributes can be the best alternative to reduce the translational gap. Thus, porcine models are used in wide areas of cancer biology. Some of the preferred cell lines/primary cells of porcine origin used in oncogenetic are:

AMC6SC8 IPEC-J2 3D4/21