Models for drug-to-drug interactions (DDI) with more clinical relevance are a serious concern for any new drug development project. The plateable hepatocytes are specialized primary liver cells, isolated from liver tissues of different species, depending upon customer requirements. These cells display a unique property of being able to adhere and grow on culture plates or dishes. These cells are used as indispensable tools for researchers in drug development, toxicology, disease modeling, as well as liver-related studies.
At Kosheeka, these cells are tested for high viability and healthy culture duration. The cells isolated at Kosheeka support the multiple potential of DDI, as they are induction-qualified. The cells are characterized by 3 major mechanisms:
- Transporter activity
- Enzyme activity
These cells are featured for their confluence monolayer and distinct morphology with a cobblestone appearance. Inducibility of enzyme activity for CYP3A4, CYP2B6, and CYP1A2. Basal metabolism for 8 CYPs, SULT, UGT, and aldehyde oxidase are analyzed for the product. These cells are pretested for long-term culture, spheroid formation, and 96-well compatibility.
- Low clearance metabolism studies
- Disease modeling
- 3D cell culture
- Short-term cellular toxicity studies