In drug development projects, there is a significant concern about finding models for drug-to-drug interactions (DDI) with clinical relevance. Plateable hepatocytes, specialized primary liver cells, are derived from various species according to customer requirements. These cells possess a unique ability to adhere and grow on culture plates or dishes, making them indispensable tools for drug development, toxicology, liver-related studies, and disease modeling.
At Kosheeka, we ensure that these hepatocytes are thoroughly tested for high viability and sustained healthy culture duration. The possess induction qualifications, making them highly valuable for DDI studies. These cells undergo comprehensive characterization for transporter activity and enzyme activity, focusing on major mechanisms involved in drug interactions.
The featured characteristics of these hepatocytes include confluence monolayer, distinct cobblestone appearance, and inducibility of enzyme activity for CYP3A4, CYP2B6, and CYP1A2. We also analyse their basal metabolism for 8CYPs, SULT, UGT, and aldehyde oxidase. Additionally, we pretest these cells for long term culture, spheroid formation, and compatibility with 96-well plates.
Choose our plateable hepatocytes to enhance the clinical relevance of your drug development projects and ensure accurate predictions of drug interactions for better research outcome.