Hematopoietic Stem Cells- Everything About it!

Hematopoietic Stem Cells- Everything About it!

The stem cells that produce all other blood cells are known as hematopoietic stem cells (HSCs). Hematopoiesis is the name for this process. Hematopoietic stem cells (HSC) are the instigators behind definitive hematopoiesis or the continual synthesis of blood cells throughout the lifespan of an organism. Each HSC is developed to produce the cellular blood components efficiently. Some of the key points on HSC which you should be aware of are listed below:

  • Hematopoietic stem cells are exceptional cells with pluripotency and self-renewal abilities that can generate the entire hematopoietic system.
  • Various subsets of hematopoietic stem cells have been found in adult hematopoiesis, and they have been observed at specific phases of embryonic development.
  • The perceived significance of hematopoietic stem cells in stable and stress hematopoiesis is still debated.
  • Human allogeneic hematopoietic stem cell transplantation therapy has severe immunological obstacles.
  • The goal of ongoing and prospective research is to find essential stem cell regulators as well as strategies for manipulating stem cells in vitro and in vivo, particularly genome editing.

HPCs are being used to replenish or repair a patient’s hematopoietic system in the treatment of numerous malignant (e.g., leukemia, lymphoma) and non-malignant (e.g., sickle cell disease) disorders. A bone marrow or stem cell transplant is the terminology for this sort of treatment. HPCs have even been used in clinical trials under the direction of the US Food and Drug Administration for the treatment of autoimmune illnesses, hereditary diseases, and other conditions.

A list of disorders for which stem cell transplantation may be a possibility is provided below:

  1. Bone Marrow: Bone marrow cells contains primary cells and are obtained during a one-hour surgical procedure. Anesthesia is frequently administered to donors or patients. If required, bone marrow can also be cryopreserved, or frozen, which is a frequently used method when it is retrieved for use in an autologous transplant. In most cases, the frozen cells are kept in a liquid nitrogen freezer.
  2. Umbilical Cord Blood Another source of Hematopoietic stem cells is umbilical cord blood (UCB), which was formerly thought to be a biological waste. Following the birth of the infant, obstetricians or birthing professionals can safely collect UCB. UCB is gathered in a bag in both circumstances. The unit is then subsequently processed (mainly to remove red blood cells) and cryopreserved (frozen) before being stored in a liquid nitrogen freezer for future use.
  3. Peripheral Blood Progenitor Cells Peripheral blood progenitor cells are also a great source of hematopoietic stem cells. An apheresis apparatus, which works like a centrifuge to take whole blood from the donor and segregate its components, is used to remove the cells from the peripheral blood. If needed, PBPCs can also be cryopreserved or frozen, which is a typical process when they are obtained for an autologous transplant. Liquid nitrogen freezers are commonly used to store frozen cells.

If you are looking for hematopoietic stem cells, or want to know more about them then connect with KOHEEKA at info@kosheeka.com

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