COVID-19 Cell Culture Tools: Is There Any Clinical Relevance?

COVID-19 Cell Culture Tools: Is There Any Clinical Relevance?

Researchers from all over the world are studying the mechanisms driving SARS-CoV-2 infection as the global COVID-19 epidemic progresses. New insights for generating therapies, vaccinations, and diagnostic tools have made possible advancements in the research. The respiratory tract epithelium offers a physical barrier against pathogens during virus infection. Understanding this barrier is considerably aided by having well enough and standardized epithelial cell culture models. The ability to simulate the many features and activities of the respiratory tract in vitro is essential for efficiently converting research findings into real-world medical applications.

Cell Lines v/s Primary cells

The major drawbacks of using cell lines are that the cell lines are frequently generated from tumor tissues, and their gene and protein expression patterns are altered or modified. As a result, cell lines cannot provide accurate information about how SARS-CoV-2 interacts with human tissue. 

However, utilizing human primary airway epithelial cells for experiments enables researchers to investigate how the SARS-CoV-2 virus interfaces with a host organism. This differs from researching the virus in cell lines, that are frequently obtained from tumor tissue and have altered protein and genes expression patterns. As a result, cell lines cannot provide a complete picture of how COVID-19  interacts with human tissue.

To properly defeat SARS-CoV-2, it is crucial to understand the molecular mechanisms of COVID-19 viral infection. Cell culture has been utilized more extensively than any other paradigm. Cell cultures, including cell lines, stem cell lines, and patient primary cells, are being investigated as in vitro models to study viral entrance into human cells.

Stem Cell Lines as a Culture Tool

Stem cell lines, on the other hand, such as mesenchymal and induced pluripotent stem cells (iPSCs), have the intrinsic ability to multiply endlessly if given adequate growth signals and nowadays, they are rapidly being used in the treatment of COVID-19 and post COVID.

In the circumstances, when a patient’s cells are unavailable, iPSCs can be developed into a variety of progenitors, including immune cells, cardiomyocytes, and neurons, for procedures such as COVID-19 drug testing to examine possible drug toxicity and other side effects. iPSCs have also been designed to create 3D cell cultures known as organoids to enhance biological experiments in a 3D environment and to emulate better in vivo situations.

In conclusion, cell cultures have aided research into the biology of SARS-CoV-2 infection and are often used for drug screening; they are also beneficial for creating viral particles and treatments. Cell cultures have shown to be an invaluable tool for biological research, and they will play an important role in the ongoing fight against COVID-19.

Kosheeka is a leading manufacturer of human primary cells and cell culture products, is providing its expertise to help experts around the world study, comprehend, and combat this new health concern. By offering well-characterized and standardized human basic cells as well as matching specialized cell culture media, Kosheeka emphasizes its role as a passionate supporter of scientific research and innovation. In addition to their range of cell culture equipment, their team of scientists is available to assist with any research needs or questions involving COVID.

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