In recent times, PDX models or patient-derived xenograft models are getting heavily utilized in head and neck oncology research, specifically for studies on radiation response and organoids. What is a Patient-Derived Xenograft? Patient-derived xenografts (PDX) are xenograft models that have been derived from patient tumor tissues but never adapted to grow like cell line-derived xenografts. Patient-derived...
Preclinical research models of cancer, such as human tumor xenografts, murine tumor homografts, cell line models and 3D organoid models, are extensively used in research and development for oncology studies. Since these tumor models are used for a wide spectrum of research applications, they are often utilized globally but the cell lines which are used...
Experiments and assays of your research lead to the establishment of a research paper but the validation of your research work comes only after your research paper is published in an appropriate esteemed journal. Besides validation, publications can extend a wider recognition, promotion, and help in gaining research funds. Unfortunately, publishing is generally easier said...
Pericytes are vascular cells located on capillaries and other small diameter vessels. They have also been reported to be present in the layers of the arteries called intima, media, and adventitia. Their exact functions are yet to be classified. Pericytes are involved in the development, stabilization, remodeling, and maturation of capillaries and other small vessels. ...
Cell culture refers to culturing the cells of organisms in an environment that supports their growth. The basic aspect of life is explained by the concept of cells. The study of cells allows the study of the various processes occurring in our bodies. With our bodies exposed to so many chemicals every day, it becomes...
Once upon a time, the scientific world was struggling to culture the notoriously difficult primary cells; and had to spend a lot of resources, in terms of money as well as time. Apart from being difficult to extract, these fragile cultures also had to pass through extremely harsh dissociation steps, and a risk of being...
Despite the significant efforts made in understanding of various aspects of cancer such as progression, metastasis, tumor microenvironment, we have achieved very limited clinical success. It is majorly because cancer is a heterogeneous disease having varied histopathology, genetic differences making difficult to understand disease mechanism as well as discover therapeutic agents for it. The heterogeneity in...
Pancreatic islets Pancreatic islets, also called islets of Langerhans, are groups of cells present in pancreas named after the the German physician Paul Langerhans, who first described them in 1869. The normal human pancreas contains about one million islets. Pancreas plays an essential role in converting the food into fuel for the body’s cells. The...
Experiments with primary cells are playing a major role in advancement of life science and pharmaceutical research. Primary cells are little difficult to work with, but these cells provide more meaningful data in experiments. Here are ten common mistakes that are made with primary cells and also how these mistakes can be minimized. These tips will enhance...
Cell culture technology is playing a major role in the advancement of modern biotechnology especially in the area of human health, medicine and pharmaceutical technology. Ideally, the cells used in cell culture systems should mimic those present in vivo, thus primary cells (non-immortalized cells that have recently been removed from an in vivo environment) have...
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