mesenchymal stem cells

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The pinnacle of biomedical research is the ongoing development of cancer medicines. The strong therapeutic potential exists when the immune system is targeted and biological processes are used to enhance the body’s response to cancer. Mesenchymal stem cells (MSCs) are a particular kind of cell that may develop into several types of tissue and play […]

Mesenchymal stem cells (MSCs) are multipotent adult stem cells. Being mutipotent, MSCs can differentiate into more than one specialized cell of the body. Generally, MSCs make the different cells in skeletal tissues e.g., chondrocytes, osteoblast, adipocyte etc. In case of MSCs giving rise to other specialized cells like neurons, reprogramming of the cells with gene […]

Role of Pericytes

The vasculature tissue consists of different types of cells: smooth muscle cells, endothelial cells, connective tissue cells, and pericytes (Johnson et al., 2002). Pericytes were discovered by Charles Marie Benjamin Rouget, a French physiologist, 140 years ago (Herndon et al., 2017). Pericytes are present in every vascularized body tissue and cover 22 to 99 % […]

Mesenchymal stem cells are easily isolated from bone marrow and other body tissues, such as adipose, umbilical cord, and peripheral blood. All mesenchymal stem cells have a multipotent differentiation capacity into a variety of cell types, like osteoblasts, chondrocytes, adipocytes, and myoblasts. Human circulating mesenchymal stem cells, also called human peripheral blood mesenchymal stem cells, […]

challenges_and_controversies_in_human

Multiples studies are being undertaken for mesenchymal stem cell transplantation in various neurological diseases like autism, stroke, cerebral palsy, etc.

Mesenchymal Stem Cells in Osteoarthritis

Osteoarthritis is a progressive degenerative disease that causes disability and chronic pain with reduced mobility, generally in knee joints. The pathophysiology includes lesions and loss of cartilage volume, leading to joint inflammation. Most current osteoarthritis treatments focus on pain management and surgical intervention but do not help in reducing the progression or reversing the condition. […]

Human Dental Mesenchymal Stem Cells and Neural Regeneration

Injuries in central and peripheral nervous system result in paralysis, anesthesia, disturbance of consciousness, and lack of motor control. Due to a limited ability of repair in case of neural damage, patients have to suffer from neurological diseases and their various after-effects. Human embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells have […]

Human bone marrow-derived mesenchymal stem cells (MSCs) have elicited great interest in the domains of tissue engineering, wound healing, regenerative medicine, and transplantation. Previous research studies have demonstrated that the transplantation of MSCs to an ectopic site in animal models has given rise to osteoblasts and bone tissue. Human bone marrow-derived mesenchymal stem cells are […]

Human Umbilical Cord-derived Mesenchymal Stem cells - Kosheeka

The human umbilical cord tissue was regarded as medical waste until 1991 when fibroblast-like cells were isolated from the human umbilical cord tissue. Further characterization of these cells revealed that they express adhesion molecules (CD44, CD105), integrin markers (CD29, CD51), and mesenchymal stem cell markers like SH2 or SH3. Pluripotency markers like Oct-4, SSEA-1, and […]

Stem Cell Therapy For COVID-19 - Kosheeka

While the world awaits a much-anticipated COVID-19 vaccine to be approved and distributed globally, several treatment options with repurposed drugs and alternative therapies are being sought after against the coronavirus disease. Among these resources, stem cell therapy has become a popular candidate with reports of successful treatment in small cohorts across the world. But do […]