Modern medicines are technologically advanced commodities. The use of completely automated analysis devices for high throughput screening is becoming more common in drug discovery. Nowadays, magnetic 3D cell culture is coming into light as it offers a more genuine model of human tissue than 2D cell culture and is one interesting high throughput technique. Magnetic...
The whole process of obtaining human tissue for studying organ development and diseases is tedious due to ethical concerns and difficulty of availability. 3D cell culture offers a unique alternative for advanced research on human tissue. 3D cell culture, in the form of organoids, is used by biomedical researchers to study the complex arrangements and...
A crucial step before taking up research work with human or animal tissue is to ensure appropriate ethical and medical legislation and guidelines for experiments. This can also deal with procuring approval from relevant authorities or individuals. Biohazards and Safety considerations It is very important to know the possible associated risks while working with potential...
Liver hepatocytes in cryopreservation contain major drug-metabolizing enzymes. For growing liver hepatocyte cell culture, a quick-thaw protocol is performed in the case of cryopreserved primary cells. However, if the thawing procedure is incorrect, the viability and functionality of the primary cells might be impaired. Inhibit Cryoinjury effects Before going for liver hepatocyte thawing, cryoinjury phenomena...
ADME is the abbreviation for Absorption, Distribution, Metabolism, and Excretion. These ADME studies are designed to investigate the metabolism and processing of a chemical compound by a living organism. When toxicology tests are a part of this process, the acronym becomes ADMET with the last T for ‘Toxicology’. Primary cells are directly isolated from human...
Cell culture is a prominent tool in cellular and molecular biology research, often spreading to clinical applications. Cell culture using primary cells can be excellent model systems for studying physiology and biochemistry of cells, drug toxicity and metabolism, and other biomedical applications. Primary cell culture is being used by researchers worldwide for their role in...
Biomedical and clinical research would be inconceivable without progress in cell culture. This tool has become inevitably crucial in life sciences and has evolved much since the early 20th century, with its application in primary cell culture, 3D culture, tissue engineering, 3D bioprinting, and regenerative therapies. As a cell culture researcher, you must have enough...
In the field of biomedical research, 2D cell cultures have extensively been used since the early 1900s but in recent times, the technology of 3D cell culture has boomed. The tussle of 2D vs 3D cell culture has received much interest from biomedical researchers and other science geeks. In this article, let us explore more...
In biomedical research and development, scientists mostly use cultured cell lines as models because they offer easy, inexpensive, and stable platforms. However, cell lines fail to grasp the microenvironment physiology that occurs in vivo. Human primary cells come to the rescue in this situation! Primary cell culture portrays the complex physiological cell behavior and therefore...
The growth of normal human mammary epithelial cells, including luminal, myoepithelial, and/or basal cells, is tightly controlled. Mammary epithelial cells grow for a finite span and eventually die or undergo senesce. Human, rat, and murine mammary epithelial cell have provided evidence that essential initial steps in mammary carcinoma cell line growth involve the loss of...
We are glad that you preferred to contact us. Please fill our short form and one of our friendly team members will contact you back shortly.
