Primary cell cultures refer to the removal of tissue from an organism and maintaining them in an appropriate medium to allow their division. One approach involves placing a piece of tissue in a glass or plastic vessel followed by bathing it in a medium. Division and growth of cells occur when cells separate from the...
Drug discovery and development extensively drives biomedical research and primary cell culture has been a very important turning point for the drug development domain. Along with primary cell culture, a critical factor in drug discovery is the study of biomarkers. The quality of biomarker detection encourages and enhances the efficiency of drug target identification, biological...
Researchers Friedenstein and his collaborators first described MSCsor mesenchymal stem cells as cells that could differentiate into other lineages and were adherent to plastic. They have generated much interest among researchers to explore the use of these cells for treating diseases on account of their ease of isolation from a variety of tissues such as bone...
According to a population-based estimate (2019), 300,000 to 400,000 individuals are affected by multiple sclerosis (MS): the most common progressive neurologic disease in the United States. The disease is considered a chronic inflammatory disease of the central nervous system (CNS) that leads to demyelination and axonal loss. The disease is complex and multi-factorial with the...
The immunomodulatory properties of mesenchymal stem cells (MSCs) coupled with their isolation from several sources ranging from bone marrow to adipose tissue to umbilical cord to placenta to dental pulp, and even menstrual fluid makes them attractive options for use in cell-based therapy. According to the National Institute of Environmental Health Sciences, autoimmune diseases affect...
Apart from serving as a source of food, pigs are considered as the ideal models of modeling human diseases. This arises from the similarity in their anatomy and physiology with that of humans. The pig genome is three times closer to our genome that that of mice. Take the example of cystic fibrosis, the introduction...
The idea that adipose tissue is a reservoir of heat and an energy source has been changed with research highlighting the tissue involved in intricate interactions with other systems of our body: cardiovascular, nervous and endocrine systems. A secretome attributed to the adipose tissue that includes growth factors and adipocytokines making this endocrine activity extremely...
Close to 35 million men in the United States face some issue of hair losswith close to 21 million women are affected by hair loss, according to a 2014 survey by the International Society of Hair Restoration Surgery (http://www.statisticbrain.com/hair-loss-statistics/). One of the most common hair loss manifestations is androgenic alopecia that targets 30 to 50%...
The reaction to a foreign substance termed as allergen is termed as an allergy. According to the Asthma and Allergy Foundation of America, allergies rank 6th as the cause of chronic illness in the US with more than $18 billion spent a year for allergies. Allergies currently lack treatments with most patients reporting “management” of...
The field of dentistry has seen many changes in terms of advances in technologies. Among the various branches of dentistry is the field of prosthodontics: that deals with the repairing of missing teeth. According to the Journal of Prosthetic Dentistry (2005), it is defined as the diagnosis and treatment of damaged or missing teeth and/or maxillofacial tissues...
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