In the early years of the current century, the applications associated with acute toxicity were largely being foreshadowed. However, very recently researchers have directed their attention to exploring many crucial biological pathways to evaluate underlying molecular the mechanism responsible for the diseased condition. In this regard, the primary cells have been emphasized to be playing...
Despite the significant efforts made in understanding of various aspects of cancer such as progression, metastasis, tumor microenvironment, we have achieved very limited clinical success. It is majorly because cancer is a heterogeneous disease having varied histopathology, genetic differences making difficult to understand disease mechanism as well as discover therapeutic agents for it. The heterogeneity in...
Pancreatic islets Pancreatic islets, also called islets of Langerhans, are groups of cells present in pancreas named after the the German physician Paul Langerhans, who first described them in 1869. The normal human pancreas contains about one million islets. Pancreas plays an essential role in converting the food into fuel for the body’s cells. The...
Experiments with primary cells are playing a major role in advancement of life science and pharmaceutical research. Primary cells are little difficult to work with, but these cells provide more meaningful data in experiments. Here are ten common mistakes that are made with primary cells and also how these mistakes can be minimized. These tips will enhance...
With the advancements made in cell culture techniques, cell culture studies provide a valuable complement to in vivo experiments and offer several advantages, such as cost effective, provide an unlimited material supply and bypass ethical concerns associated with the use of animal. In vitro studies allow more controlled experiments to study cellular functions and processes....
Many new developed pharmaceuticals turn out to be toxic, even after getting release into the market due to their unexpected side effects. These adverse drug reactions cause significant health issues to patient’s health and as well as cause financial loss to pharmaceutical industry due to post-licensing drug withdrawal from market. Adverse drug reactions are of...
Cell culture technology is playing a major role in the advancement of modern biotechnology especially in the area of human health, medicine and pharmaceutical technology. Ideally, the cells used in cell culture systems should mimic those present in vivo, thus primary cells (non-immortalized cells that have recently been removed from an in vivo environment) have...
In vitro cell culture experiments play an important role in the advancement of life science and biomedical research. These cell culture studies have become an integral part of research related to diagnosis, drug development, and drug toxicity and add significant value to the understanding of cellular and functional aspects of physiology and metabolism. However, the in vitro...
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